//ENTITIES 463257 biochemicalReaction Phosphorylation of 4E-BP1 by activated mTORC1 6977522 protein Eukaryotic translation initiation factor 4E-binding protein 1 6977357 protein FKBP12-rapamycin complex-associated protein 6977347 smallMolecule GDP 6977479 smallMolecule ADP 69773567024972 smallMolecule GTP 69773457024962 protein GTP-binding protein Rheb precursor 6967986 smallMolecule ADP 462567 biochemicalReaction Phosphorylation of PDE3B 6977388 protein 40S ribosomal protein S6 6977385 smallMolecule ATP 6977305 smallMolecule ATP 6977390 protein 40S ribosomal protein S6 6977423 smallMolecule ADP 6977450 protein Eukaryotic translation initiation factor 4 gamma 1 6977366 protein Ribosomal protein S6 kinase beta-1 462568 catalysis null 697735870250037024972 smallMolecule GTP 69775057025034 protein Eukaryotic translation initiation factor 4E-binding protein 1 6977355 protein Raptor 6977358 complex Activated mTORC1 6977356 complex Rheb:GTP 6977521 protein Eukaryotic translation initiation factor 4E 6967977 protein Cyclic GMP inhibited phosphodiesterase B 6977352 protein mLst8 461772 pathway mTOR signalling 463246 biochemicalReaction Phosphorylation of TSC2 by PKB 463251 catalysis null 463258 biochemicalReaction Dissociation of phosphorylated 4EBP1 from eIF4E 6977422 protein Elongation factor 2 kinase 6977478 protein Eukaryotic translation initiation factor 4B 69775047025018 protein Eukaryotic translation initiation factor 4E-binding protein 1 69775047025021 protein Eukaryotic translation initiation factor 4E 6977501 smallMolecule ATP 463249 biochemicalReaction Formation of active mTORC1 complex 6977306 protein Tuberin 6977345 complex Rheb:GDP 461776 pathway S6K1 signalling 463250 biochemicalReaction Activation of S6K1 6977506 smallMolecule ADP 461775 pathway S6K1-mediated signalling 463248 biochemicalReaction GTP loading by Rheb 463252 biochemicalReaction Phosphorylation of Ribosomal protein S6 by activated S6K1 6977342 smallMolecule GTP 69775057025031 protein Eukaryotic translation initiation factor 4E 6977505 complex eIF4E:4E-BP1-P 6977504 complex eIF4E:4E-BP 6977419 smallMolecule ATP 463256 biochemicalReaction Phosphorylation and activation of eIF4B by activated S6K1 6977315 smallMolecule ADP 6977449 smallMolecule ADP 6977424 protein Elongation factor 2 kinase 463247 biochemicalReaction Phosphorylation of complexed TSC2 by PKB 69679907011062 protein RAC-beta serine/threonine-protein kinase 6977445 smallMolecule ATP 6967980 smallMolecule ATP 69773587025004 protein FKBP12-rapamycin complex-associated protein 463253 catalysis null 461773 pathway Inhibition of TSC complex formation by PKB 6977330 smallMolecule ADP 461777 pathway Release of eIF4E 69773587024999 protein mLst8 6977367 smallMolecule ADP 697735870250037024975 protein GTP-binding protein Rheb precursor 69773297013350 protein Hamartin 461774 pathway mTORC1-mediated signalling 6967990 complex PIP3:Phosphorylated PKB complex 6977368 protein Ribosomal protein S6 kinase beta-1 6977305 smallMolecule ATP 69773317024942 protein Tuberin 6977331 complex TSC1:Inhibited TSC2-1-P 69773317024953 protein Hamartin 6977480 protein Eukaryotic translation initiation factor 4B 69773587025003 complex Rheb:GTP 6977389 smallMolecule ADP 6977475 smallMolecule ATP 69773567024975 protein GTP-binding protein Rheb precursor 463255 biochemicalReaction Phosphorylation and activation of eIF4G by activated S6K1 6977448 protein Eukaryotic translation initiation factor 4 gamma 1 6977329 complex TSC1:TSC2 6977315 smallMolecule ADP 69773297013347 protein Tuberin 6967981 protein Cyclic GMP inhibited phosphodiesterase B 69773457024959 smallMolecule GDP 69773587025002 protein Raptor 463254 biochemicalReaction Phosphorylation and inactivation of eEF2K by activated S6K1 6977363 smallMolecule ATP 69679907011059 smallMolecule Phosphatidylinositol-3,4,5-trisphosphate 6977326 smallMolecule ATP 6977302 protein Tuberin //INTERACTIONS 463250 6977368 output 463246 6977306 output 6977505 463258 input 6967980 462567 input 463252 6977390 output 463251 463250 controlled 462567 6967981 output 6977366 463250 input 6977445 463255 input 463250 6977367 output 6977419 463254 input 463257 6977506 output 6967977 462567 input 462568 462567 controlled 463254 6977423 output 463256 6977479 output 6977358 463251 controller 6977448 463255 input 463256 6977480 output 6967990 462568 controller 463258 6977521 output 6977475 463256 input 6977422 463254 input 463253 463252 controlled 6977357 463249 input 6977356 463249 input 6977501 463257 input 6977329 463247 input 6977345 463248 input 463248 6977356 output 463257 6977505 output 6977478 463256 input 463258 6977522 output 6977363 463250 input 463246 6977315 output 6977326 463247 input 6977504 463257 input 463247 6977330 output 6977385 463252 input 6977355 463249 input 463249 6977358 output 463255 6977450 output 462567 6967986 output 463254 6977424 output 463255 6977449 output 6977302 463246 input 463252 6977389 output 6977305 463246 input 6977368 463253 controller 6977388 463252 input 463247 6977331 output 463248 6977347 output 6977342 463248 input 6977352 463249 input //INCLUSIONS 461776 6977388 461777 463258 461776 6977389 461775 463251 6977505 69775057025034 461776 463255 461776 6977385 461776 463254 461776 6977423 461777 463257 461773 6977331 461775 461776 6977504 69775047025018 461773 6977305 6977345 69773457024959 461772 461773 461773 6977302 461773 6977315 461775 463250 461776 6977445 461774 461775 461773 6977326 6977358 69773587025002 461775 6977368 461776 6977479 461773 463247 461776 463256 461776 6977390 6977356 69773567024975 461777 6977504 461776 6977478 6977329 69773297013347 69773587025003 697735870250037024975 461772 6977342 461772 461774 6967990 69679907011059 6967990 69679907011062 461774 461777 6977358 69773587024999 461776 6977449 6977356 69773567024972 6977331 69773317024953 461772 6977345 461773 6967990 461776 6977480 461772 463249 461773 463246 461775 6977367 461775 6977363 6977504 69775047025021 461775 6977366 461776 6977419 461773 462568 461773 6977329 6977358 69773587025003 461772 6977347 461773 6977306 461776 463253 461777 6977505 461776 6977450 461776 463252 6977329 69773297013350 461777 463251 6977345 69773457024962 6977505 69775057025031 461776 6977424 461776 6977422 69773587025003 697735870250037024972 461773 462568 461772 463248 461777 6977521 461773 6977330 461772 6977355 461777 6977522 461772 6977358 461776 463253 461776 463253 461776 6977475 461776 6977448 461772 6977352 6977331 69773317024942 6977358 69773587025004 461776 463253 461772 6977356 461772 6977357 //END